PE 22-28

PE-22-28 10mg is a synthetic peptide compound developed for laboratory research involving two-pore-domain potassium channel modulation, receptor interaction analysis, and controlled experimental investigation. In research settings, this peptide is commonly utilized for studying TREK-1 channel function, synaptic plasticity and mood-circuit signaling, and related biochemical mechanisms.

PE-22-28 is a heptapeptide fragment corresponding to the C-terminal 22-28 region of spadin, the propeptide released during sortilin maturation. It selectively inhibits the TREK-1 (KCNK2) two-pore-domain potassium channel, modulating neuronal excitability in preparations from cortex, hippocampus, and dorsal raphe.

Researchers employ PE-22-28 to probe TREK-1 contributions to fast-onset antidepressant signaling, neurogenesis, and serotonergic activity in rodent brain-slice and primary-culture models. Its relative ease of synthesis compared to full-length spadin makes it the preferred tool compound for TREK-1 antagonism studies.